Gestational trophoblastic disease
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چکیده
estational trophoblastic disease includes following forms of growth disturbance of the human trophoblast: hydatiform mole, invasive mole, choriocarcinoma and placental site trophoblastic tumors. Term gestational trophoblastic disease is applied to the letter three conditions. Diagnosis and decision to institute treatment are sometimes undertaken without histopathological finding. Gestational trophoblastic disease is unique for its genetic origin, existence of ideal tumor marker bhCG and extremely high sensitivity to chemotherapy. This makes it curable in spite of its high malignant potential. Gestational trophoblastic disease appears as a result of abnormal gametogenesis and fertilization, so it represents natural neoplastic allograft with genetic material of another organism. Nongestational choriocarcinoma with primary ovarian or extragonadal localization also exists (1). Gestational trophoblastic disease can appear in any type of pregnancy. Hydatiform mole appears as a result of proliferation of cytotrophoblast and syncytiotrophoblast with different degrees of hyperplasia and dysplasia, hydropic degeneration of chorionic villi and disintegration of blood vessels. It appears as partial or complete. Disorders in partial mole are mild and focal. Karyotype is triploid, 69,XXY. Disorders of complete mole are severe in the absence of fetus or embryo. Genetic material derives from duplication of paternal haploid set (46,XX). In some cases it occurs as a result of dispermic fertilization of an empty egg (46,XY). Invasive mole (mole destruens, chorioadenoma destruens) has similar histological characteristics like a complete mole, but it is more aggressive, directly invades myometrium and its blood vessels, which often results in pulmonary embolisation. Distinction
منابع مشابه
The Gestational Trophoblastic Diseases: A Ten Year Retrospective Study
Background Gestational trophoblastic disease (GTD) defines a heterogenenous group of interrelated lesions that arise from the trophoblastic epithelium of the placenta. There are several histologically distinct types of GTD: hydatiform mole (complete or partial), persistant/invasive gestational trophoblastic neoplasia (GTN), choriocarcinoma and placenta site trophoblastic tumors. The aim of this...
متن کاملGestational trophoblastic disease I: epidemiology, pathology, clinical presentation and diagnosis of gestational trophoblastic disease, and management of hydatidiform mole.
Gestational trophoblastic disease includes hydatidiform mole (complete and partial) and gestational trophoblastic neoplasia (invasive mole, choriocarcinoma, placental site trophoblastic tumor, and epithelioid trophoblastic tumor). The epidemiology, pathology, clinical presentation, and diagnosis of each of these trophoblastic disease variants are discussed. Particular emphasis is given to manag...
متن کاملMental Representations of Illness in Patients with Gestational Trophoblastic Disease: How Do Patients Perceive Their Condition?
BACKGROUND Gestational Trophoblastic Disease comprises a group of benign and malignant disorders that derive from the placenta. Using Leventhal's Common-Sense Model as a theoretical framework, this paper examines illness perception in women who have been diagnosed with this disease. METHODS Thirty-one women diagnosed with Gestational Trophoblastic Disease in a hospital in Italy were asked to ...
متن کاملGestational trophoblastic disease: presentations from the XVIIth World Congress on Gestational Trophoblastic Diseases.
The current symposium contains a selection of papers that were presented at the XVIth World Congress on Gestational Trophoblastic Diseases in Budapest, Hungary, October 16–19, 2011. The Congress was organized under the exceptional leadership of Dr. Vilmos Fulop, the Congress Chairperson, and was extraordinarily successful in showcasing the latest advances in the basic science, population studie...
متن کاملCoexisting epithelioid trophoblastic tumor and placental site trophoblastic tumor of the uterus following a term pregnancy: report of a case and review of literature.
Gestational trophoblastic neoplasms are a group of fetal trophoblastic tumors including choriocarcinomas, epithelioid trophoblastic tumors (ETTs), and placental site trophoblastic tumors (PSTTs). Mixed gestational trophoblastic neoplasms are extremely rare. The existence of mixed gestational trophoblastic neoplasms that were composed of choriocarcinoma and/or PSTT and/or ETT was also reported. ...
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